A member of the Janus kinase family of enzymes, which play a crucial role in the signaling pathways of various cytokines and growth factors. JAK3 is primarily expressed in hematopoietic (blood-forming) cells and is involved in the signaling of several interleukins, particularly those that are important for immune function.
Mutations in the JAK3 gene can lead to constitutive activation of the pathway, promoting uncontrolled cell proliferation and survival.
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