The JUN proto-oncogene is a gene that encodes a protein called c-Jun, which is a component of the AP-1 (Activator Protein 1) transcription factor complex.
Jun is a key component of the AP-1 (Activator Protein 1) transcription factor complex, which plays a significant role in regulating gene expression in response to various stimuli, including growth factors, stress, and cytokines. The Jun family includes several proteins, such as c-Jun, JunB, and JunD, which can have distinct roles in cancer biology.
In many cancers, Jun, particularly c-Jun, is activated and promotes cell proliferation, survival, and invasion. This activation is typically associated with poor prognosis and aggressive tumor behavior.
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