MAP2K1, also known as MEK1, is a gene that encodes a protein involved in the MAPK/ERK signaling pathway, which plays a crucial role in cell proliferation, differentiation, and survival.
MAP2K1 mutations are found in several types of cancer, including melanoma, lung cancer, and colorectal cancer. These mutations can lead to constitutive activation of the MAPK pathway, promoting uncontrolled cell growth and survival.
MEK inhibitors, which block the activity of MEK1 and its counterpart MEK2, are being investigated in clinical trials for various cancers, particularly those with MAPK pathway alterations.
MAP2K1 is found to be overexpressed, which can lead to enhanced activation of the MAPK/ERK signaling pathway. This overexpression is often associated with aggressive tumor behavior and poor prognosis. For example, elevated levels of MAP2K1 have been observed in certain types of melanoma and colorectal cancer.
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