MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) is a gene that encodes a protein involved in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival.
Some studies suggest that MAP3K1 may function as a tumor suppressor in certain types of cancer. Mutations or deletions in the MAP3K1 gene have been observed in various cancers, including breast cancer and melanoma, which may lead to altered signaling pathways that promote tumorigenesis.
MAP3K1 interacts with other signaling pathways, including the PI3K/AKT and NF-κB pathways, which are also critical in cancer biology. This crosstalk can influence tumor growth and response to therapies.
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