MEN1, or Multiple Endocrine Neoplasia type 1, is a genetic disorder that affects the endocrine system and is characterized by the development of tumors in multiple endocrine glands. It is caused by mutations in the MEN1 gene, which is a tumor suppressor gene. The condition is also known as Wermer's syndrome.
Individuals with MEN1 are at an increased risk for several types of tumors.
The MEN1 gene, which encodes the protein menin, plays a crucial role in various cellular processes, including cell proliferation, apoptosis, and gene regulation.
Loss of menin function due to mutations in the MEN1 gene can lead to uncontrolled cell proliferation and tumorigenesis.
MEN I is inherently protumorigenic due to the genetic predisposition conferred by mutations in the MEN1 gene. The loss of menin function leads to dysregulation of cell growth and proliferation, contributing to the development of endocrine tumors.
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