ASXL1 might act as a tumor suppressor in CRC. ASXL1 is a tumor suppressor gene and its downregulation or deletion is expected to confer a growth advantage to cells.
ASXL1 expression loss or mutation is primarily associated with hematological malignancies, where it generally indicates a poorer prognosis.
Tumor Suppressor Function: ASXL1 is involved in chromatin remodeling and gene regulation, which are critical processes for maintaining normal cellular function and preventing uncontrolled cell growth. When ASXL1 is mutated or its expression is lost, it can lead to dysregulation of gene expression, contributing to tumorigenesis.
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