MLL3 (Mixed-Lineage Leukemia 3) is a gene that encodes a protein involved in the regulation of gene expression, particularly in the context of development and differentiation. It is part of the MLL family of proteins, which are known to function as histone methyltransferases, modifying chromatin structure and influencing transcriptional activity.
MLL3 can act as a tumor suppressor in certain contexts, meaning that its loss or inactivation may promote cancer development.
MLL3 is often considered a tumor suppressor gene. Loss-of-function mutations or deletions of MLL3 can lead to reduced expression or complete loss of the protein, which may contribute to tumorigenesis.
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