Gene, which encodes the thrombopoietin receptor. This receptor plays a crucial role in the regulation of hematopoiesis, particularly in the production of platelets.
Myeloproliferative leukemia virus oncogene (MPL) is often mutated or overexpressed in various hematological malignancies, particularly myeloproliferative neoplasms. Its expression is associated with disease progression and can influence prognosis. MPL is generally considered protumorigenic due to its role in promoting cell proliferation and survival in the context of blood cancers.
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