NOTCH2 is a member of the Notch signaling pathway, which plays a crucial role in cell differentiation, proliferation, and apoptosis.
NOTCH2 can act as either a tumor suppressor or an oncogene.
Notch2 expression varies widely across cancer types. In some tumors, such as certain hematological malignancies and solid tumors like breast or lung cancer, Notch2 may be overexpressed or exhibit enhanced signaling activity.
– In contrast, other studies have observed reduced expression of Notch2 in tumors like hepatocellular carcinoma or pancreatic cancer, suggesting that its role can differ based on tissue context and tumor subtype.
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