PAX5 (Paired Box 5) is a transcription factor that plays a crucial role in the development of B cells, which are a type of white blood cell involved in the immune response. It is primarily expressed in B-lineage cells and is essential for B cell differentiation and function.
PAX5 mutations can lead to the loss of function of the protein, which may result in the inability of B cells to properly differentiate. This can create an environment conducive to the development of leukemia or lymphoma.
PAX5, as a key transcription factor in B-cell development, plays a critical role in the pathogenesis of B-cell malignancies. Its alteration—commonly observed as mutations, deletions, or fusion events—can impair normal differentiation and contribute to oncogenesis. In this setting, normal PAX5 function is tumor suppressive, and its disruption generally correlates with a more aggressive disease and poorer prognosis.
(Will delete Record if Target field = "Delete") Home