PBRM1 (Polybromo 1) is a gene that encodes a protein involved in chromatin remodeling and regulation of gene expression. It is part of the PBAF (Polybromo-associated BAF) complex, which plays a crucial role in various cellular processes, including cell cycle regulation, differentiation, and response to DNA damage.
Mutations or alterations in the PBRM1 gene have been associated with several types of cancer, particularly renal cell carcinoma (RCC).
In many cases, reduced expression or functional loss is the dominant pattern rather than overexpression.
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