PDGFRA (Platelet-Derived Growth Factor Receptor Alpha) is a receptor tyrosine kinase that plays a significant role in cell growth, survival, and differentiation. It is part of the PDGF family, which includes various growth factors that bind to PDGF receptors to regulate cellular functions.
Cancers, such as gastrointestinal stromal tumors (GISTs), are often associated with mutations in the PDGFRA gene.
Imatinib (Gleevec) is a tyrosine kinase inhibitor that is effective in treating GISTs with PDGFRA mutations.
PDGFRA overexpression is reported in several tumors. However, more notably, mutations (often gain-of-function) or gene amplifications in PDGFRA are key oncogenic events in certain cancer types.
(Will delete Record if Target field = "Delete") Home