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tid Target Cancers General Effect on Target
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BAP1 is the most frequently mutated deubiquitinase in human cancers and is a major tumor suppressor.BRCA-1 associated protein 1 (BAP1) is a tumor suppressor gene that has been implicated in the pathogenesis of several malignancies.
Normal fibroblast cell cultures in individuals with heterozygous loss of BAP1 exhibited increased glycolysis and decreased aerobic mitochondrial respiration.




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