PHF6 (PHD finger protein 6) is a gene that encodes a protein involved in various cellular processes, including transcriptional regulation and chromatin remodeling.
PHF6 is a gene with tumor-suppressive functions that is frequently altered (usually by loss-of-function mutations or decreased expression) in several hematologic malignancies such as T-ALL and AML. Its inactivation is generally associated with features of aggressive disease and poor prognostic indicators. In solid tumors, more research is necessary to define the exact clinical implications. Overall, a normal PHF6 function appears crucial for proper chromatin regulation and gene expression, and its disruption contributes to oncogenic processes through deregulated transcription and impaired differentiation.
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