SMARCA4, also known as BRG1, is a gene that encodes a protein involved in the SWI/SNF chromatin remodeling complex. This complex plays a crucial role in regulating gene expression by altering the structure of chromatin, making DNA more or less accessible for transcription.
SMARCA4 is considered a tumor suppressor gene. Loss of function mutations in SMARCA4 can lead to the disruption of normal chromatin remodeling, contributing to uncontrolled cell growth and tumorigenesis.
In many cancers, particularly those with mutations or deletions in the SMARCA4 gene, there is often a loss of expression of the SMARCA4 protein. This loss can lead to dysregulation of chromatin remodeling and contribute to tumorigenesis.
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