SPOP (Speckle-type POZ protein) is a gene that encodes a protein involved in various cellular processes, including transcriptional regulation and protein degradation.
SPOP mutations are most commonly associated with prostate cancer. In this context, SPOP is often found to be mutated rather than simply overexpressed or underexpressed. These mutations can lead to the loss of its normal function, which is to promote the degradation of certain proteins, including the androgen receptor. This dysregulation can contribute to the development and progression of prostate cancer.
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