Also known as serine/threonine kinase 11
STK11, also known as LKB1 (Liver Kinase B1), is a tumor suppressor gene that plays a crucial role in regulating cell metabolism, growth, and polarity.
Enzymatic activity is crucial for regulating various cellular processes, including metabolism, cell growth, and cell cycle progression. The gene's role as a tumor suppressor is linked to its ability to control these processes, and mutations in STK11 can lead to the development of various cancers.
In many cancers, particularly those associated with mutations in the STK11 gene, there is often a loss of STK11 expression or function.
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