Diseases associated with ACVR1B include Pancreatic Cancer.
Activin A receptor type IB (ACVR1B) is a gene that encodes a signaling protein that functions in growth and differentiation.
The prognostic value of ACVR1B expression can vary:
High Expression: In some cancers, high levels of ACVR1B may be associated with poor prognosis, indicating aggressive tumor behavior.
Low Expression: Conversely, low expression levels may correlate with better outcomes in certain contexts.
Tumor Suppressor Role
In some contexts, ACVR1B has been suggested to have tumor suppressor-like functions:
Inhibition of Proliferation: ACVR1B can mediate growth inhibition in certain cell types, and its activation may lead to apoptosis in response to specific signals.
Regulation of Cell Cycle: It may play a role in regulating the cell cycle, which is a critical aspect of tumor suppression
Oncogenic Role
Conversely, in other contexts, ACVR1B may exhibit oncogenic properties:
Tumor Progression: In some cancers, altered expression of ACVR1B can be associated with tumor progression and metastasis.
Context-Dependent Effects: The effects of ACVR1B can vary based on the presence of other signaling molecules and the specific tumor microenvironment.
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