BRAF is a gene involved in controlling cell growth.
BRAF mutations are present in approximately 10%-15% of colorectal cancers, 35% of melanomas, and more than 50% of thyroid papillary carcinomas. The majority of BRAF mutations are V600E mutations.
the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation has been observed in esophageal cancer and is associated with poor prognosis.
It encodes a protein that is part of the RAS-RAF-MEK-ERK signaling pathway, which is involved in regulating cell division, differentiation, and survival. When BRAF is mutated, particularly in the form of the BRAF V600E mutation, it can lead to constitutive activation of the signaling pathway, promoting uncontrolled cell growth and contributing to the development of various cancers, most notably melanoma.
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