TNFAIP3, also known as A20, is a protein that plays a critical role in regulating immune responses and maintaining cellular homeostasis. It functions primarily as a negative regulator of the NF-κB signaling pathway, which is involved in inflammation, immune response, and cell survival.
In certain solid tumors, such as some breast or colorectal cancers, the loss or silencing of TNFAIP3 may contribute to increased NF-κB activity, leading to a more aggressive phenotype.
(Will delete Record if Target field = "Delete") Home