The thyroid-stimulating hormone receptor (TSHR) is a G protein-coupled receptor that plays a crucial role in regulating thyroid function by mediating the effects of thyroid-stimulating hormone (TSH) on the thyroid gland. TSHR is primarily involved in the synthesis and release of thyroid hormones.
The TSHR gene encodes the thyroid-stimulating hormone receptor (TSHR), which is a G protein-coupled receptor located on the surface of thyroid follicular cells. This receptor is crucial for the regulation of thyroid hormone synthesis and secretion in response to thyroid-stimulating hormone (TSH), which is produced by the pituitary gland.
TSHR expression is well established as a marker of differentiation and prognosis in thyroid cancer, with lower levels generally indicating a worse prognosis.
More aggressive thyroid cancers (poorly differentiated or anaplastic thyroid carcinoma) may show reduced or lost TSHR expression, which is associated with a worse prognosis.
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