U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a protein that plays a crucial role in the splicing of pre-mRNA, which is an essential step in gene expression. It is part of the spliceosome complex, which is responsible for removing introns from pre-mRNA and joining exons together to form mature mRNA.
Mutant U2AF1 contributes to a protumor phenotype by misregulating alternative splicing, potentially leading to the production of aberrant protein isoforms that disrupt normal cell differentiation and promote survival and proliferation.
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