The Wilms tumor 1 (WT1) gene is a critical gene associated with the development of Wilms tumor, a type of kidney cancer that primarily affects children.
WT1 is highly expressed in many solid tumors (such as ovarian, breast, lung, and colorectal cancers) as well as hematologic malignancies (e.g., acute leukemias).
WT1 is generally overexpressed in many cancers and is associated with aggressive tumor behavior and poorer prognosis in several contexts. Its multifunctional nature, marked by its ability to act as both a transcriptional activator and repressor, underlies its complex role in tumorigenesis.
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