γδ T-cells are a unique subset of T-cells that play a significant role in the immune response, particularly in the context of cancer. Unlike conventional αβ T-cells, γδ T-cells possess distinct T-cell receptors (TCRs) composed of gamma and delta chains. This unique structure allows them to recognize a wide range of antigens, including those derived from stressed, infected, or transformed cells, making them particularly interesting in cancer immunology.
– In many studies, higher levels or functional anti-tumor γδ T-cell activity (especially IFN-γ producing γδ T cells) have been associated with improved patient outcomes.
– Their capability to recognize and directly kill stressed or transformed cells contributes to tumor immune surveillance.
– γδ T cells can produce pro-inflammatory cytokines (like IFN-γ) that support anti-tumor immune responses.
– Alternatively, in certain microenvironments, they may secrete IL-17 or other factors that could promote tumor-associated inflammation and even angiogenesis.
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