L-Type Amino Acid Transporter 1 (LAT1) mediates the uptake of essential amino acids and its expression is upregulated during the progression of several cancers. By upregulating amino acid transporters, cancer cells gain greater access to exogenous amino acids to support chronic proliferation, maintain metabolic pathways, and to enhance certain signal transduction pathways.
In many cancers it is unregulated, particularly those with high metabolic demands, LATs, especially LAT1, facilitate the uptake of essential amino acids that support protein synthesis, cell growth, and proliferation. This is typically associated with poor prognosis and aggressive tumor behavior.
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