LAT gene (linker for activation of T cells). As an adaptor protein, the function of LAT in TCR signaling centers upon its tyrosine phosphorylation and subsequent recruitment of other signaling proteins.
LAT (Linker for Activation of T cells) plays a significant role in T cell signaling and immune responses, with its expression levels and functional outcomes varying across different cancer types. Generally, decreased LAT expression is associated with worse prognosis in many cancers, indicating its potential role as a tumor suppressor through the enhancement of anti-tumor immunity.
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