A mutation in the SUFU gene, this means you have a condition called Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS).
The expression levels of SUFU were significantly decreased in gastric cancer cells and the tumor tissues of gastric cancer patients.
Sufu is a key negative regulator of the Hedgehog (Hh) signaling pathway, which is involved in cell differentiation, proliferation, and tissue patterning.
• By inhibiting Gli transcription factors downstream of Hh signaling, Sufu helps moderate pathway activity.
• Aberrant Hh pathway activation—often through genetic or epigenetic disruption of Sufu—has been implicated in the development and progression of various cancers.
Sufu serves as a negative regulator of the Hh pathway, and its reduced expression or loss-of-function mutations can result in increased Hh signaling, promoting tumorigenesis.
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