A gene that encodes a protein that is a receptor tyrosine kinase in the vascular endothelial growth factor receptor (VEGF) family.
Flt4 has also been shown to be expressed selectively in subsets of cancer cells.
FLT4 (Fms-related tyrosine kinase 4), also known as VEGFR-3 (Vascular Endothelial Growth Factor Receptor 3), is primarily involved in lymphangiogenesis and has been studied in various cancers. Its expression can be associated with tumor progression, metastasis, and prognosis in different cancer types.
FLT4 over expression is often associated with aggressive tumor behavior and poor prognosis across various cancer types.
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