Perlecan is overexpressed in the desmoplastic prostate cancer stroma. knockdown of perlecan in metastatic prostate cancer cells reduces in vivo tumor growth.
Also known as basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) or heparan sulfate proteoglycan 2 (HSPG2), is a protein that in humans is encoded by the HSPG2 gene.
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