Activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis.
GnT-V, or N-acetylglucosaminyltransferase V (also known as MGAT5), is an enzyme involved in the glycosylation of proteins, specifically in the addition of N-acetylglucosamine (GlcNAc) residues to the core structure of N-glycans. This enzyme plays a significant role in the modification of glycoproteins, which can influence various cellular processes, including cell adhesion, signaling, and immune response.
GnT-V expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in promoting tumor aggressiveness and metastasis. Its involvement in glycosylation processes can influence cell behavior, including adhesion and migration, which are critical for cancer progression.
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