NM23 is a metastasis suppressor gene. Reductions in Nm23-H1 expression have been significantly associated with aggressive behavior in gastric carcinoma, ovarian cancer, melanoma, and breast cancer.
NM23 genes are typically expressed in many tissues under normal conditions.
– In several cancers, particularly metastatic tumors, the expression of NM23 (especially NM23-H1) can be reduced compared to primary tumors, consistent with its role as a metastasis suppressor.
Low NM23 expression has been associated with increased metastatic potential in cancers such as breast, melanoma, and hepatocellular carcinoma.
– In these contexts, decreased NM23 levels often correlate with a poorer prognosis and enhanced tumor aggressiveness.
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