IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways. IMPDH2 expression has been found to be vastly dysregulated in several cancer types, promoting pro-tumorigenic phenotypes and leading to an elevated IMPDH2/IMPDH1 ratio.
Many cancers have high levels of IMPDH2 and is associated with increased tumor proliferation, aggressiveness, and poorer overall survival. Its expression often correlates with a more aggressive tumor phenotype.
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