HEC1 (also known as HEC1 or NDC80) is a protein that is part of the NDC80 complex, which is crucial for the proper functioning of the mitotic spindle during cell division. It plays a significant role in the attachment of microtubules to kinetochores, ensuring accurate chromosome segregation during mitosis. Dysregulation of HEC1 has been implicated in various cancers, and its expression levels can have prognostic implications.
Hec1 is often overexpressed in cancers with poor prognosis.
Hec1 is significantly upregulated in cervical cancer tissues and associated with poor prognosis in cervical cancer patients.
Its overexpression is associated with various cancers, including breast, lung, ovarian, and colorectal cancers, often correlating with poor prognosis and aggressive tumor behavior. While HEC1 itself is not classified as a traditional oncogene, its dysregulation contributes to oncogenic processes, making it a potential target for therapeutic intervention and a candidate biomarker for cancer prognosis.
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