The phosphorylation of PRAS40 is often associated with the tumor progression of melanoma, prostate cancer, etc. Elevated PRAS40-Thr 246 phosphorylation has been reported in several cancer cell lines.
PRAS40 serves as an important mediator linking Akt signaling to mTORC1 activation. In many cancers—such as breast, lung, and colorectal—enhanced Akt activity leads to increased phosphorylation of PRAS40, thereby promoting tumor cell survival, proliferation, and growth. These changes are often associated with more aggressive tumor behavior and poorer outcomes.
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