Also 3BHS1, 3BH, HSDB3, and HSD3B
HSD3B refers to 3β-hydroxysteroid dehydrogenase, an enzyme that plays a critical role in steroid hormone biosynthesis. There are several isoforms of this enzyme, with HSD3B1 and HSD3B2 being the most studied. These enzymes catalyze the conversion of pregnenolone to progesterone and the conversion of dehydroepiandrosterone (DHEA) to androstenedione, which are important steps in the synthesis of various steroid hormones.
HSD3B1 is a gene that encodes an enzyme involved in steroid hormone biosynthesis and metabolism.
HSD3B expression has been observed in various cancers, particularly those that are hormone-dependent, such as breast, prostate, and ovarian cancers.
HSD3B is involved in steroid hormone biosynthesis and has been implicated in various cancers, particularly hormone-dependent tumors. Its expression levels may have prognostic significance, and while it is not classified as an oncogene, its role in hormone metabolism can influence cancer progression and treatment response
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