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tid Target Cancers General Effect on Target
Name
Source
Type

Hormone therapy — slows cancer growth by lowering testosterone levels in the body.
"shaking up prostate cancer with high-dose testosterone makes it more vulnerable to other treatments."
There is a higher incidence of prostate cancer among men with low testosterone.

Prostate cancer is highly sensitive to androgenic stimulation. Testosterone—and more potently, its derivative dihydrotestosterone (DHT)—binds to the androgen receptor (AR) in prostate cells, which can drive the growth and survival of both normal and malignant cells.

Castration-Resistant Prostate Cancer (CRPC):

Even after testosterone levels are medically reduced, some prostate cancers continue to thrive by adapting their AR pathway. CRPC often signals a transition to a more aggressive, treatment-resistant state.




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