IRP1, a well-known iron regulatory protein, an important element in the regulation of iron homeostasis in animal cells.
Glioma patients with high expression of IRP1 had better survival prognosis.
Protumorigenic Effects
Iron Homeostasis: IRP1 regulates iron metabolism, and its upregulation can lead to increased iron availability, which supports tumor growth and proliferation.
Oxidative Stress: Elevated iron levels can contribute to oxidative stress, promoting DNA damage and tumor progression.
Cellular Proliferation: By enhancing iron uptake, IRP1 can support the metabolic demands of rapidly dividing cancer cells.
Generally, IRP1 has higher expression in cancers and is associated with worse prognosis, indicating its potential role in promoting tumors.
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