Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene family. CBL gene, a part of the Cbl family, encodes the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.
There are three mammalian Cbl proteins encoded by separate genes: Cbl (a.k.a., c-Cbl, CBL2, RNF55), Cbl-b (a.k.a., RNF56), and Cbl-c (a.k.a., Cbl-3, Cbl-SL, RNF57;)
Cbl functions as a tumor suppressor by E3-dependent ubiquitination and downregulation of activated RTKs. Cbl can function also as an oncogene by mediating adaptor function-dependent activation of downstream signaling to the PI3K/AKT pathway.
CAS-BR-M MURINE ECOTROPIC RETROVIRAL TRANSFORMING SEQUENCE C; CBLC
(Will delete Record if Target field = "Delete") Home