Cholinesterase is an enzyme that plays a crucial role in the nervous system by breaking down the neurotransmitter acetylcholine.
Some studies have found that cholinesterase inhibitors, which are compounds that block the activity of cholinesterase, may have anti-cancer effects.
Butyrylcholinesterase (BCHE) is a type of cholinesterase that has been found to be overexpressed in certain types of cancer, including breast, colon, and lung cancer.
Acetylcholinesterase (AChE) is another type of cholinesterase that has been found to be involved in the development and progression of certain types of cancer. Inhibitors of AChE have been shown to have anti-cancer effects in preclinical studies.
In general, alterations in cholinesterase activity, particularly AChE and BChE, can be associated with tumor behavior and prognosis in various cancer types. While high levels of cholinesterases may correlate with better outcomes in some cancers, the specific implications can vary depending on the cancer type and other molecular factors.
High AChE activity has been associated with better prognosis, while low activity may correlate with more aggressive disease.
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