ATFs respond to extracellular signals, indicating their important roles in maintaining homeostasis. The ATF family includes ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7. Consistent with the diversity of cellular processes reported to be regulated by ATFs, the functions of ATFs are also diverse. ATFs play an important role in cell proliferation, apoptosis, differentiation and inflammation-related pathological processes. ATF (Activating Transcription Factor) proteins are a family of transcription factors that play crucial roles in various cellular processes, including stress responses, metabolism, and cell differentiation. In the context of cancer, several ATF family members have been implicated in tumorigenesis, cancer progression, and prognosis. Here are some key points regarding ATFs and their expression in cancers with prognostic implications. ATF3:
Often associated with stress responses, ATF3 can have dual roles in cancer. In some contexts, it acts as a tumor suppressor, while in others, it may promote tumor growth.
High expression of ATF3 has been linked to poor prognosis in certain cancers, such as breast cancer and pancreatic cancer. ATF4:
ATF4 is involved in the integrated stress response and can promote cell survival under stress conditions.
Its expression is often elevated in various cancers, including glioblastoma and multiple myeloma, and has been associated with poor prognosis due to its role in promoting survival and resistance to therapy. ATF6:
ATF6 is part of the unfolded protein response (UPR) and is involved in maintaining cellular homeostasis.
Its expression has been linked to cancer cell survival and may correlate with poor outcomes in certain malignancies. ATF1:
ATF1 is involved in regulating genes associated with cell proliferation and survival.
Its expression levels can vary in different cancers, and its prognostic significance is still being explored. ATF2:
ATF2 has been implicated in both promoting and inhibiting cancer progression, depending on the context.
Elevated levels of ATF2 have been associated with poor prognosis in some cancers, such as melanoma.
(Will delete Record if Target field = "Delete") Home