P70S6K, or p70 S6 kinase, is a protein kinase that plays a significant role in the signaling pathways related to cell growth, proliferation, and survival. It is part of the mTOR (mechanistic target of rapamycin) signaling pathway, which is crucial for regulating cellular metabolism and growth in response to nutrients, growth factors, and stress signals.
Expression Direction:
In many cancers, p70S6K is frequently found to be overexpressed or hyperactivated.
Increased phosphorylation (activation) of p70S6K is often detected, correlating with enhanced mTOR signaling.
Elevated levels or hyperactivation of p70S6K in tumor tissues are generally associated with:
More aggressive tumor behavior and higher proliferative indices.
A poorer prognosis in several cancer types.
• In cancers such as breast, lung, and gastrointestinal cancers, high p70S6K activity may correlate with advanced disease and decreased overall survival.
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