Also known as HSPA1A
HSP72, or Heat Shock Protein 72, is a member of the heat shock protein family, which plays a crucial role in cellular stress responses. It is also known as HSPA1A and is involved in protein folding, protection against stress-induced damage, and the regulation of apoptosis (programmed cell death).
HSP72 can help cancer cells survive under stressful conditions, such as those found in the tumor microenvironment (e.g., low oxygen, nutrient deprivation). This ability to protect cells from stress can contribute to tumor growth and resistance to therapy.
Elevated levels of HSP72 have been associated with resistance to various cancer treatments, including chemotherapy and radiation. Cancer cells that express high levels of HSP72 may be more capable of repairing damage caused by these therapies, leading to treatment failure.
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