CUL4B (Cullin 4B) is a member of the Cullin family of proteins, which are part of the ubiquitin-proteasome system. This system is crucial for regulating protein degradation and maintaining cellular homeostasis. CUL4B specifically plays a role in the ubiquitination process, where it helps tag proteins for degradation, thereby influencing various cellular processes, including cell cycle regulation, DNA repair, and response to stress.
Elevated levels of CUL4B have been associated with certain types of cancers, including breast cancer and others, suggesting that it may act as an oncogene in these contexts.
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