CBP is a transcriptional coactivator that plays a crucial role in regulating gene expression, and it has been implicated in various cellular processes, including cell growth, differentiation, and apoptosis.
CBP is of interest because it can influence the activity of oncogenes and tumor suppressor genes.
CBP can act as an oncogene in certain contexts. Its ability to enhance the transcription of genes that promote cell proliferation and survival can contribute to tumorigenesis. Overexpression of CBP has been observed in various cancers, including breast, colon, and prostate cancers.
CBP may also function as a tumor suppressor. For instance, mutations or loss of CBP expression can lead to the activation of oncogenic pathways. This dual role can depend on the specific cellular context and the presence of other signaling molecules.
CBP interacts with numerous transcription factors, including p53, which is a well-known tumor suppressor. The interaction between CBP and p53 is crucial for p53's role in regulating the cell cycle and apoptosis. Dysregulation of this interaction can lead to cancer development.
Overexpressed: breast,CRC, prostate, lung, HCC, ovrian, bladder, pancreatic, head and neck, AML.
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