ZBTB10, which was an important target of miR-27a, suppressed the expression of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR1), VEGFR2 and survivin which were responsible for angiogenesis and metastasis of cancer.
Downregulation of ZBTB10 has been noted in contexts where high miR-27a expression suppresses its levels, indirectly leading to the upregulation of genes that promote tumor progression.
Lower levels of ZBTB10 have been associated in some studies with more aggressive tumor behavior and poorer prognosis.
– The rationale is that reduced ZBTB10 expression may lead to unchecked Sp1 activity, driving the expression of pro-tumorigenic genes involved in proliferation, angiogenesis, and survival.
Current evidence suggests that ZBTB10 may function as a tumor suppressor by inhibiting Sp1-dependent oncogenic pathways. In several cancers, reduced expression of ZBTB10—often driven by microRNA-mediated repression—correlates with enhanced tumor progression and poorer outcomes.
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