ACTA2 (Actin Alpha Cardiac Muscle 2) is a gene that encodes a protein involved in the structure and function of smooth muscle cells. It plays a crucial role in various physiological processes, iACTA2 has been studied for its role in the tumor microenvironment, particularly in relation to cancer-associated fibroblasts (CAFs) and the extracellular matrix. CAFs, which often express ACTA2, can influence tumor progression, metastasis, and response to therapy. ncluding muscle contraction and the maintenance of vascular tone.
High levels of ACTA2 are often correlated with aggressive tumor behavior and poor patient outcomes.
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