NEDD9 (Neural Precursor Cell Expressed Developmentally Downregulated 9) is a protein that has been implicated in various cellular processes, including cell adhesion, migration, and signaling. It is part of the CAS (Crk-associated substrate) family of proteins and is known to interact with several signaling pathways, particularly those involving integrins and growth factor receptors.
NEDD9 is often found to be overexpressed in various types of cancers, including breast, lung, and colorectal cancers. This overexpression is associated with more aggressive tumor behavior and poorer prognosis.
NEDD9 interacts with several signaling pathways, including those mediated by epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases. These interactions can enhance signaling pathways that promote cell survival, proliferation, and migration.
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