NPY and Y2R are overexpressed in human Colon cancer, orthotopic HT29, and most interestingly in VEGF-A-depleted orthotopic HT29 tumours.
NPY favors tumor cell growth, migration, and metastasis and promotes angiogenesis in some tumors (e.g., breast cancer, colorectal cancer, neuroblastoma, pancreatic cancer), whereas in others it exerts an antitumor effect (e.g., cholangiocarcinoma, Ewing sarcoma, liver cancer).
Increased NPY signaling has been correlated with aggressive features in certain tumors, as it may promote cell proliferation, angiogenesis, and migration.
– In cancers where NPY receptor expression is high, particularly the Y1 and Y2 receptors, the activation of NPY signaling cascades can correlate with poorer prognosis, tumor growth, or enhanced metastatic potential.
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