Interferon-γ-inducible protein 10 (IP-10), also known as CXCL10, is a chemokine that plays a significant role in immune responses, particularly in the recruitment of immune cells to sites of inflammation and infection. Its expression has been studied in various cancers, and it has implications for tumor behavior and the immune response.
Interferon-γ-inducible protein 10 is a potent chemoattractant for natural killer cells and activated T lymphocytes. It also displays angiostatic properties and some antitumor activity.
IP-10 upregulation correlated with shorter survival provides evidence that IP-10 plays a functional role in pancreatic cancer.
Interferon-γ-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects.
Mixed Prognosis: The prognostic implications of IP-10 in cancer can vary. In some cases, high levels of IP-10 may correlate with a favorable immune response and better prognosis, while in other contexts, it may be associated with tumor progression and poor outcomes.
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