NSE, (or gamma-enolase or enolase 2) is a cytosolic protein consistently expressed by mature neurons and cells of neuronal origin.
NSE is commonly used as a marker for neurons and neuroendocrine cells, making it a useful tool for assessing neuronal injury and neuroendocrine tumors.
Neuron-specific enolase (NSE) has become a widely used and easily attainable laboratory assay of small cell lung cancer (SCLC). Elevated serum NSE before any therapy of SCLC patients may be a negative prognostic factor for OS and PFS.
The level of NSE correlates with tumour burden, number of metastatic sites and response to treatment.
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